Our portfolio of innovative and dependable liquid chromatography (LC) instruments includes analytical HPLC and UHPLC systems to handle any separation challenge from simple to complex samples; application-specific HPLC and UHPLC systems for applications such as 2D-LC and dual LC; and nano-, capillary- and micro-flow UHPLC systems for highly sensitive proteomics, metabolomics, and intact protein analysis.

Our easy-to-use systems minimize the need for training while providing high-quality, dependable performance to give you confidence in your results. Our LC systems come in a variety of configurations, so there is one to fit your needs.

In addition to our LC instruments, we offer a variety of detection options from reliable UV-Vis-based detection to selective and sensitive mass spectrometry. Our offerings also feature a large selection of HPLC and UHPLC columns in a variety of chemistries, particle sizes, and dimensions to support your applications. You will also find HPLC and UHPLC fittings, tubing, vials, well plates and other consumables for optimal system performance and better chromatographic results.

Vanquish Core HPLC System

Deliver reliable results with the Thermo Scientific™ Vanquish™ Core HPLC systems. Built on the Vanquish HPLC platform, the Vanquish Core HPLC system enables your lab to evolve to meet both current and future needs. New enhancements such as System Health Monitoring and the Vanquish Solvent Monitor, provide increased productive time for your system. An integrated display and detailed maintenance videos empower your operators to maintain a flow of high-quality results. A full suite of method transfer tools, including tunable gradient delay volume, makes adoption easy.

Vanquish Flex UHPLC System

Obtain new benchmarks in accuracy, precision and sensitivity with the Thermo Scientific™ Vanquish™ Flex UHPLC systems. Providing biocompatibility with a state-of-the-art quaternary or binary high-pressure solvent blending, these ultra-high performance liquid chromatography systems share all Vanquish values, such as a design focused on uptime, robustness and reliability. Multiple detection options give you the performance and flexibility you need. These system are ideal for method development or high-throughput analyses and can be seamlessly coupled to a mass spectrometer (MS).

Vanquish Horizon UHPLC System

Designed with innovative technology and fine detail, the Thermo Scientific™ Vanquish™ Horizon UHPLC System delivers a new standard in high-end UHPLC—more results with better separations and easier interaction simultaneously, without compromise. Conceived for the uniquely efficient 1.5µm solid core particle Thermo Scientific™ Accucore™ Vanquish™ C18 UHPLC column, this fully integrated and biocompatible system features high sample capacity for high-throughput workflows, industry-leading pumping performance, amazingly high S/N and linearity, two-mode thermostatting, active preheating, and more in a system that's driven by the gold-standard CDS software.

Vanquish Duo UHPLC System

Use the Thermo Scientific™ Vanquish™ Duo UHPLC Systems to support four workflows (Dual LC, Tandem LC or LC-MS, Dual LC-MS and Inverse Gradient) by combining two flow paths in one integrated UHPLC solution. These workflows improve your productivity by saving time, reducing cost per sample, increasing capacity without added bench, and using your resources more efficiently. Vanquish Duo UHPLC Systems expand the benefits of the Vanquish platform without compromising performance, robustness, or ease-of-use.

UltiMate 3000 RSLCnano System

Get outstanding performance and workflow versatility using the Thermo Scientific™ UltiMate™ 3000 RSLCnano system. This low-flow liquid chromatography system has a wide flow-pressure footprint with nano-, capillary-, and micro-flow options. Our advanced Thermo Scientific™ ProFlow™ technology improves nano-flow rate control and results in high retention time precision and gradient reproducibility. Achieve high-sensitivity and excellent separation with our nano-flow solution, or balance sensitivity and high-throughput with standardized, robust capillary- and micro-flow solutions.

Vanquish Variable Wavelength Detector

Achieve excellent linearity and noise performance across a wide operating range with Thermo Scientific™ Vanquish™ variable wavelength detectors. These detectors can be integrated into Thermo Scientific™ Vanquish™ HPLC and UHPLC systems when you need more versatile, robust, high-performance UV-Vis absorption detection to measure your sample. With up to 250 Hz data acquisition, the detector keeps pace with any current and future HPLC and UHPLC detection challenges. Select from a wide flow-cell portfolio to match your application related requirements.

Vanquish Diode Array Detector and Multi Wavelength Detector

Get the best performance, reliability, and flexibility in HPLC and UHPLC detection with Thermo Scientific™ Vanquish™ Diode Array Detectors (DAD) and Multiple Wavelength Detectors (MWD). These detectors offer excellent linearity and optimized noise performance, and feature an ultra-wide dynamic range to allow detection of highly concentrated main compounds alongside trace-level impurities.

In addition, the Vanquish DAD HL uses Thermo Scientific™ LightPipe™ technology to achieve the best signal-to-noise performance through a combination of low baseline noise, a very long light path, and minimal dispersion.

Vanquish Fluorescence Detector

Get trace detection performance through highly effective stray light suppression with Thermo Scientific™ Vanquish™ Fluorescence Detectors. These detectors reduce thermal effects using temperature-controlled flow cells for increased detection precision. Monitor up to four wavelength pairs simultaneously, or scan your chromatogram for the best emission/excitation wavelengths. Improve detection sensitivity and selectivity by leveraging ultrafast wavelength switching between peaks.

RefractoMax 521 Refractive Index Detector

For cost-effective analysis of compounds with little or no absorption in the UV range, use the Thermo Scientific™ RefractoMax 521 Refractive Index Detector. It is ideal for detection of alcohols, sugars, carbohydrates, fatty acids and polymers in combination with an isocratic Thermo™ Scientific™ Dionex™ UltiMate™ 3000 system. Low baseline noise and high response make it suitable for sensitive analyses. Flow rates from 1 to 10mL/min. and linear detection of 1.00–1.75 RIU support a range of HPLC applications.

Vanquish Charged Aerosol Detector

Utilize the increased separation speed and resolution of the Thermo Scientific™ Vanquish™ UHPLC system to detect and quantify virtually any substance using the near-universal detection capabilities of Vanquish Charged Aerosol Detectors. With enhanced linear dynamic range and accurate, consistent response, this detector can measure low-level impurities and active pharmaceutical ingredients (APIs) simultaneously, as well as other compounds, regardless of chemical structure. One can measure virtually any nonvolatile and most semivolatile analytes with sub-nanogram sensitivity. The charged aerosol detector expands the capabilities for discovery and is a powerful addition to any chromatography lab.